Jiri Lehecka claimed the last semifinal spot in the Madrid Open main draw after Daniil Medvedev withdrew injured at one set down on Thursday.
In a repeat of last year's final, Aryna Sabalenka and Iga Swiatek will face off once again at the Madrid Open final.
Carlos Alcaraz's quest for a third successive Madrid Open title was ended by a shock quarter-final defeat to Andrey Rublev.
Iga Swiatek is through to the Madrid Open semifinals after beating Maia Haddad 4-6 6-0 6-2 on Tuesday.
Jiri Lehecka made easy work of former world number one Rafael Nadal, defeating him in straight sets in the fourth round of the Madrid Open on Tuesday.
Rafael Nadal reached the fourth round of the Madrid Open with a hard-fought win over Argentina's Pedro Cachin on Monday evening.