All-rounder Senuran Muthusamy scored his maiden Test ton (109) and Marco Jansen smashed a brisk 93 (91) to boost South Africa to 480 all out on Day Two of the second Test.
India captain Shubman Gill has been cleared to travel to Guwahati for the second Test against South Africa despite being doubtful to play due to a neck injury.
The deciding third T20 between England and South Africa was called off without a single delivery being bowled due to persistent rain.
Proteas captain Temba Bavuma suffered a calf strain during the disastrous third ODI against England on Sunday.
For the second consecutive series, South Africa collapsed in a dead rubber match, suffering a record-breaking 342-run loss to England in the third and final ODI in Southampton.
South African off-spinner Prenelan Subrayen has been cleared to continue bowling in international cricket following an independent assessment of his bowling action by the International Cricket Council (ICC).