Springbok flyhalf Manie Libbok and flanker Marco van Staden are part of a fresh side that looks to test new combinations against Italy on Saturday.
Scotland have confirmed their autumn international schedule, which includes a blockbuster clash against the world champion Springboks in November.
The Springbok Sevens finished their HSBC SVNS Perth campaign on a high note by outplaying France 24-5 to finish the tournament in fifth place.