Three-time Grand Slam finalist Ruud has become the latest star to pull out of the grass-court major as "playing best-of-five sets is unfortunately a bit too soon" for the Norwegian as he joins Arthur Fils and Sebastian Korda on the sidelines.
Ruud was set to be seeded 15th at the All England Club, but his manager has confirmed that he is not ready to make his comeback just yet following his recent knee injury.
"He's back on the court, and things are going well, but it looks like playing best-of-five sets is unfortunately a bit too soon. Gstaad will be next for Casper now," manager Tina Falster told NTB.
The former world No. 2 has struggled with the injury for several months as he missed his Geneva Open title defence, but then made his return at the French Open before suffering a second-round exit.
Afterwards, he admitted that players are under pressure to play mandatory tournaments due to the ATP Rankings system.
"You feel you're obligated to play with certain rules that the ATP have set up with the mandatory events. You feel like you lose a lot if you don't show up and play, both economically, point-wise, ranking-wise and opportunity-wise," the 26-year-old said.
Fils, meanwhile, aggravated a back injury during his five-set win over Jaume Munar in the second round at Roland Garros and was forced to withdraw from his home Grand Slam ahead of his third-round match.
Scans later revealed that he had a stress fracture.
"I had some issue with the back since a long time and during the match against Munar it [got] worse," the French No. 1, who was due to be seeded 16th, said. "Then I did some exams. The exams were not good at all. [I] got some stress fracture."
Korda was projected to be seeded 30th, but he also hasn't played since losing in the third round at the French Open.
"Unfortunately, no Wimbledon for me this year," the American wrote on Instagram. "Stress fracture in my shin during the clay. Been a tough 12 months, but better days ahead."
There have been no big-name withdrawals from the women's draw at Wimbledon with the top 32 seeds all set to feature in the third Grand Slam of the year.